EREN and Esen (for cross-sectional studies) have set up numerous epidemiological studies.

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The NutriNet-Santé study was set up to investigate nutrition and health relationships. Specifically, it was the first web-based cohort worldwide on such a large scale (n=160 000 as of 2017) focused on the complex link between nutrition and health status. It is characterized by a very detailed assessment of nutritional exposure and dietary behavior. A biobank comprising samples of serum, plasma, and buffy-coats for genetic analyses, as well as urine samples was set up for 19 600 subjects of the cohort. It represents a unique platform for establishing multidisciplinary research projects and collaborations, with the capability and flexibility to add ancillary protocols and questionnaires and thus rapidly collect large amounts of high-quality data. Our ambition is to expand NutriNet-Santé to other countries. It has already been launched in Belgium and pilot studies are ongoing in Switzerland, Spain, Canada and Mexico. Our team is a pioneer of e-epidemiology at the international level having conducted numerous methodological research investigations in this field.

EREN was the first research team in France to obtain authorization by the State Council (in 2012) to link data from our cohorts with data from the national health insurance system (which includes detailed information on prescription medication use, sick leaves, etc). In addition to augmenting our databases, such access allows us to set up specific programs focused on long-term drug use in interaction with nutrition.

Go to Etude-Nutrinet-Santé

See also the Nutrinet-Santé institutional website

suvimaxThe "Supplementation en VItamines et Minéraux AntioXydants" (SU.VI.MAX) Study is a randomized double-blind, placebo-controlled, primary-prevention trial designed to test the efficacy of a daily supplementation with antioxidant vitamins and minerals, in reducing cancer and ischaemic vascular disease incidence in a general population. 14,412 subjects living in France (women aged 35 to 60, and men 45 to 60) were selected from 79,976 volunteers enrolled after a five-month  (March-July 1994) national multimedia campaign.  Of these subjects 13,017 were assigned at random to one of two groups. Immediately after randomisation, 270 subjects declared that they were no longer willing participate in the study and 6 subjects were recognised as ineligible (out of the age range after verification).  Supplementation consisted to a combination of 120 mg vitamin C, 30 mg vitamin E,  6 mg beta-carotene,  100 µg selenium (as selenium-enriched yeast) and 20 mg zinc (as gluconate);  or a matching placebo in a single daily capsule. At enrolment and at 12-18 months intervals, participants were invited to visit a mobile medical unit or a preventive health center. Subjects were asked to complete a monthly questionnaire, summarising treatment compliance and health events, via Minitel (a phone-based French terminal), the internet or mail. Primary outcomes were major ischaemic events (ICD codes 120-124) and cancer of any kind, except for basal cell carcinoma of the skin. Secondary outcome was all-cause mortality. After a median follow-up time of 7.5 years, intention-to-treat comparisons were performed between both groups.

etude SU.VI.MAX 2Study involving a cohort of adults who were enrolled in the initial SU.VI.MAX trial (a randomised, double-blind, placebo-controlled intervention trial launched in 1994 to test the impact of daily nutritional doses of anti-oxidant vitamins and minerals administrated over 8 years). The main objective of the SU.VI.MAX2 study was to investigate the relationships between overall dietary behaviours (dietary patterns) and/or specific nutritional factors (intake or blood concentrations of anti-oxidants, folate, n-3 polyunsaturated fatty acids (PUFA), protein and energy intake) and quality of aging. The exposure variables were estimated from data collected during 1994-1996 (eg, baseline SU.VI.MAX data). The aging outcomes were evaluated 10-12 years later (2007-2009). Using self-administrated questionnaires and clinico-biological examinations, we collected information on cognitive function, mood, wellbeing, social integration, nutritional status, bone health, balance impairment, sensory problems, physical performance and mobility and prevalent diseases. Neuro-psychological examinations were performed by health professionals recruited specifically for this purpose.

The study was carried out on a sample of 7,000 subjects: 3,500 women and 3,500 men aged 55-70 years who had volunteered to participate in this post-supplementation observational follow-up.

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Health Study on Environment, Biomonitoring, Physical activity and Nutrition 2014-2016.

The French Nutrition and Health Program (PNNS) wished the renewal ofthe National Nutrition and Health Survey (ENNS-2006) in order to provide reliable comparative data on the situation about the nutritional surveillance in terms of evolution. It is in this framework that Santé publique France (the French National Public Health Agency) have set up the Health Study on Environment, Biomonitoring, Physical Activity and Nutrition (Esteban) to meet objectives on biomonitoring, chronic diseases surveillance, and nutritional surveillance (dietary intakes, physical activity and nutritional status). The Esen (Nutritional Surveillance and Epidemiology Team) was in charge of analyzing the nutritional aspect of this study and providing comparison with the results of ENNS.

Esteban was implemented in a national sample including 6-17 year old children and 18-74 year old adults living in France. Following a three-degree sampling plan, the subjects inclusion was carried out between April 2014 and March 2016 to take into account the seasonality of the diet and eventual exposures. Data collection concerned sociodemographic, behavioral and environmental questionnaires, food questionnaires and a health examination with anthropometric measurements and biological sample. The dietary recalls concerned 1,281 children and 2,835 adults. Health examinations concerned 1,104 children and 2,503 adults.

logo sufolom small1Randomised, double-blind, placebo-controlled secondary prevention clinical trial with cardiovascular disease (CVD) survivors (N=2,501; aged 45-80 years). It employed a 2x2 factorial design (4 possible combinations) as well as B vitamins and n-3 PUFA delivered at nutritional doses. Specifically, individuals who had experienced a myocardial infarction (MI), an acute coronary attack without necrosis or an ischemic stroke in the 1 to 12 months prior to their enrolment in the study were randomly allocated to one of the 4 possible combinations:

  1. Double placebo
  2. Placebo and B vitamins (5-methyl-THF, 560 µg; vitamin B6, 3 mg; vitamin B12, 20 µg)
  3. Placebo and long chain n-3 PUFA (600 mg EPA and DHA in a 2:1 ratio)
  4. Both B vitamins and n-3 PUFA

The follow-up lasted 5 years during which time a Biobank and a DNA database (DNAthèque) were established. The principle outcomes included the development of a recurrent MI, stroke or death due to a cardiovascular problem. Secondary outcomes included: mortality (any cause), hospital admission due to CVD or coronary artery disease, or hospitalisation due to vascular disease. Follow-up questionnaires were sent to the participants every 6 months in order to collect information on newly developed health events (disease, hospital admissions...) and on the evolution of risk and protective factors (eg, diet, smoking, physical activity...). The intervention terminated in July 2009.

Cohort implemented to test the hypothesis that early life dietary habits are the major determinants of the risk of obeisty and metabolic diseases in adulthood. The secondary objectives of the study were:

  1. To analyse the evolution of food intake by age in order to comprehend the effect of dietary habits on food choices in adulthood
  2. To study the influence of physical activity on growth parameters
  3. To evaluate the evolution of growth and development (trajectory and speed of growth) and its association with futur risks

The ELANCE study was launched in 1985 and the participants were followed from the age of 10 months to 20 years. In the biginning, children were examined in child health centres (n=162 seen at the age of 10 months, 2 years and 4 years). After the age of 6 years, children were visited at home (n=126 examined at 6 years, n=112 at 8 years, n=104 at 10 years and n=94 at 16 years). Examinations consisted of anthropometric measurements (weight, height, waist circumference, skin folds), questions on dietary intakes (at all ages) and on physical activity (starting from 10 years of age). Other information concerning gestational age, weight and height at birth, method and duration of milk feeding and family history of diseases was collected from the mothers. At 20 years, 74 participants were examined in medical centres for adults. Biological analyses were performed to assess, among other factors, the hormonal status (leptin, ghrelin and growth factors).

Cross-sectional study performed in 2006-2007 with the main objective of assessing food consumption, physical activity, sedentary lifestyle and nutritional status of children (3-17 years) and adults (18-74 years) residing in metropolitan France. The secondary objectives were to describe the prevalence of diabetes (diagnosed or undiagnosed), metabolic diseases, hypertension, dyslipidemia, the nutritional risk factors for such diseases, and the medical and dietary treatments used by the adults included in the study. The study sample was randomly selected via a 3-steps random drawing: 3 115 adults and 1 675 children were enrolled over a period of 1 year, which minimised the effect of seasonal changes in behaviours, in particular those related to diet and physical activity. Data on socio-demographic characteristics, life conditions, smoking, physical activity, sedentary lifestyle, drug use and medical history were collected using questionnaires which were either self-administrered or completed during face-to-face interviews. The study also used three 24-hour food recalls randomly spread over a period of 15 days. A clinical check-up and biological tests were also part of the investigation and consisted in measuring weight and height (in children and adults), waist and hip circumference, blood pressure, total cholesterol, HDL, LDL, triglycerides, haemoglobin, ferritin, glycemia, creatinine, folate and vitamin D (in adults).

Cross-sectional study set up in 2004-2005 for the purpose of evaluating dietary habits and nutritional status of food-aid program beneficiaries. This study used several food-aid program structures (eg, subsidized groceries, food/meal distribution centres) in 4 urban areas (Paris, Seine-Saint-Denis, Dijon and Marseille). A random sample of 1 164 food-aid beneficiaries (aged 18+ years) was recruited. We collected data socio-demographic and economic characteristics, food supply sources including food-aid programs and frequency of consumption of the major food groups/nutrients. We also conducted clinical examinations and blood sample collection in public health centres.

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visuel eren

Highlights 2012-2017